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Figure 2 | Veterinary Research

Figure 2

From: Delineating transcriptional crosstalk between Mycobacterium avium subsp. paratuberculosis and human THP-1 cells at the early stage of infection via dual RNA-seq analysis

Figure 2

Functional analysis of genes differentially expressed in intracellular MAP. A Top 20 KEGG pathways listed according to the FDR value. Enrichment analysis was performed using the GSEA tool with customized KEGG gene sets (level C). B Network analysis of enriched pathways by EnrichmentMAP. Enriched pathways (p < 0.5) in intracellular MAP generated by the GSEA tool were exported to Cytoscape and grouped by the EnrichmentMAP application (red: positive-NES, blue: negative-NES). C The distribution of differentially expressed genes (DEGs) in the virulence factor upper categories (gray: nonsignificantly differed VFG-annotated loci, red: upregulated DEGs, blue: downregulated DEGs). D Top 5 upper categories associated with DEGs (red: upregulated DEGs, blue: downregulated DEGs). A vertical red dotted line indicates the threshold of the p value (p = 0.05).

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Veterinary Research

ISSN: 1297-9716